Antithrombotic therapy in nonvalvular atrial fibrillation: A narrative review

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Antithrombotic therapy in nonvalvular atrial fibrillation: a narrative review.

Atrial fibrillation (AF) is an important and potentially modifiable cause of stroke. It has been known since 1989 that oral anticoagulant drugs, such as warfarin, lead to a dramatic decrease in stroke associated with AF. The best risk-benefit ratio is obtained with intensity of oral anticoagulant treatment for an INR of 2-3, even in the elderly. Given the risks of anticoagulant therapy, includi...

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Antithrombotic therapy in atrial fibrillation.

Abbreviations: ACUTE 5 Assessment of Cardioversion Using Transesophageal Echocardiography; AF 5 atrial fibrillation; AFASAK 5 Atrial Fibrillation Aspirin and Anticoagulation; AFI 5 Atrial Fibrillation Investigators; BAATAF 5 Boston Area Anticoagulation Trial for Atrial Fibrillation; CAFA 5 Canadian Atrial Fibrillation Anticoagulation; CI 5 confidence interval; DC 5 direct current; EAFT 5 Europe...

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Nonvalvular atrial fibrillation and stroke: a review.

Nonvalvular atrial fibrillation accounts for more than thirty percent of all strokes above the age of sixty years. The use of anticoagulants for the primary prevention of stroke has been a controversial issue for a long time. New data has emerged which clarifies some of these issues and helps in selecting patients who are at a higher risk of stroke.

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Antithrombotic therapy for atrial fibrillation.

Pooled estimate 1 2.5 (1.8-3.5) .59 (for heterogeneity) Studies included in pooled estimate: AFI 2/ 1994 2.5 (NR) , .05 SPAF I-III Aspirin 3/ 1999 2.9 (NR) , .001 Stöllberger et al 4 /1998 3.7 (1.5-7.5) .002 Wang et al 5 /2003 1.9 (1.1-3.3) NR Studies not included in pooled estimate: AFI Echo 6 /1998a 3.5 (1.8-6.7) , .001 Aronow et al 7 /1998 1.6 (1.1-2.2) , .009 Hart et al 8 /2000 (intermitten...

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ژورنال

عنوان ژورنال: Revista Portuguesa de Cardiologia

سال: 2011

ISSN: 0870-2551

DOI: 10.1016/j.repc.2011.09.014